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VSV-hIFN-B
- Development stage
- Phase 1
- Lead developer
- Mayo Clinic
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Gene Therapies
- Administration
- Intravenous, Intratumoral
01
Overview
VSV-hIFN-β is an oncolytic virus, specifically a vesicular stomatitis virus (VSV), that has been engineered to express human interferon-beta (hIFN-β). This novel immunotherapy approach is designed to selectively infect and kill tumor cells while simultaneously stimulating an anti-tumor immune response in the host. It was developed for the treatment of hepatocellular carcinoma, a liver cancer with limited treatment options. Mayo Clinic Arizona received an approximately $600,000 grant from the FDA to fund a Phase 1 clinical study of VSV-hIFN-β for this indication.
- Other names
- Recombinant vesicular stomatitis virus-expressing interferon-betaVSV-hIFN-betavesicular stomatitis virus-interferon beta
02
Targets
IFNAR (Immune system modulation via type I interferon receptor)
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