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VSV-HSV1-sr39tk
- Development stage
- Preclinical
- Lead developer
- Technical University of Munich
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Gene Therapies
- Administration
- Intratumoral
01
Overview
**VSV-HSV1-sr39tk** is an investigational recombinant oncolytic vesicular stomatitis virus engineered to express the mutant herpes simplex virus type 1 thymidine kinase reporter gene, **HSV1-sr39tk**. In a preclinical orthotopic hepatocellular carcinoma model in immunocompetent Buffalo rats, the virus was administered intratumorally and enabled noninvasive PET imaging of infected tumors using the HSV1-sr39tk reporter system while retaining the lytic antitumor activity of oncolytic VSV. It has been reported as a preclinical research vector rather than a marketed or clinical-stage product. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC4395780/))
- Other names
- VSV-HSV1-sr39tkVSV-HSV-1-sr39tkVSV-HSV 1-sr39tkrVSV-HSV1-sr39tkrVSV-HSV-1-sr39tkrVSV-HSV 1-sr39tk
02
Targets
HSV-TK Mut2 (Herpes simplex virus type 1 thymidine kinase mutant SR39)
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