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Drug intelligence / Profile preview
vsv-indiana hiv gag
- Development stage
- Phase 1
- Lead developer
- Aurobindo Pharma
- Modality
- Vaccines & Immunotherapeutics, Viral Vectors → Gene Addition/Replacement → Gene Therapies
- Administration
- Intramuscular
01
Overview
VSV-Indiana HIV gag is a recombinant viral vector vaccine candidate developed by Profectus BioSciences in collaboration with the National Institute of Allergy and Infectious Diseases (NIAID). It utilizes a live-attenuated, replication-competent Vesicular Stomatitis Virus (VSV) Indiana serotype vector engineered to express the HIV-1 Gag protein. The Gag protein is a highly conserved internal structural protein of HIV, intended to elicit robust T-cell mediated immune responses. The vaccine has been evaluated in Phase 1 clinical trials both as a standalone agent in healthy volunteers and as a booster following DNA vaccine priming (such as the Profectus HIV MAG pDNA vaccine) in both HIV-uninfected and HIV-infected individuals. The goal of this approach is to induce long-lasting cellular immunity to control or prevent HIV infection.
- Brand names
- VesiculoVax HIV gag vaccine
- Other names
- rVSV-HIV-1 gagrVSV-HIV1 gagrVSV-HIV 1 gagrecombinant vesicular stomatitis virus HIV-1 gag vaccinerVSV-Indiana HIV-1 gag
02
Targets
Gag (HIV-1 Gag polyprotein)
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