Drug intelligence / Profile preview

vTau

Development stage
Preclinical
Lead developer
Vaxine
Modality
Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

vTau is an active immunotherapy candidate developed by the Australian biotechnology company Vaxine, designed to target pathological tau protein in the brain. The vaccine consists of a recombinant human tau protein formulated with Vaxine's proprietary Advax adjuvant, which is derived from delta-inulin. vTau is intended for the treatment of Alzheimer's disease and other tauopathies, where the accumulation of hyperphosphorylated tau into neurofibrillary tangles is a hallmark of neurodegeneration. By inducing a robust humoral immune response, the vaccine stimulates the production of anti-tau antibodies that facilitate the clearance of extracellular tau and inhibit the cell-to-cell template-driven spread of tau pathology, potentially slowing cognitive decline.

Other names
Vaxine tau vaccinerecombinant tau vaccine
02

Targets

Tau aggregates (Microtubule-associated protein tau (pathological form))

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