VU0155069

VU0155069 is a potent and selective small molecule inhibitor of phospholipase D1 (PLD1), with an IC50 of 46 nM for PLD1 and significantly less activity for PLD2 (IC50 of 933 nM)[1][4][7]. It robustly blocks invasive migration of cancer cell lines in vitro and suppresses activation of the inflammasome, reducing IL-1β production and caspase-1 activation in macrophages[3][4][6][10]. Preclinical studies demonstrated that VU0155069 strongly enhances survival in sepsis models by inhibiting lung inflammation, leukocyte apoptosis, and proinflammatory cytokine production, making it a tool compound for cancer biology, inflammation, and immunology research[3][10]. It is not approved for human therapeutic use and is intended for laboratory research only.

Other names

VU0155069VU-0155069VU 0155069CAY10593CAY-10593CAY 10593compound 69compound69compound-69