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VVD-130850
- Development stage
- Unknown
- Lead developer
- Vividion Therapeutics
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
VVD-130850 is an investigational, orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3), developed by Vividion Therapeutics for the treatment of advanced solid tumors, hematologic malignancies, non-Hodgkin's lymphoma, and non-small cell lung cancer. It binds to a novel allosteric pocket on STAT3, directly inhibiting its DNA binding activity and downstream gene expression without affecting STAT3 protein levels. The drug is being evaluated as both a single agent and in combination with immune checkpoint inhibitors in Phase I clinical trials. Its development leverages Vividion’s chemoproteomics platform to identify unique allosteric modulators for challenging targets.
- Other names
- STAT3 inhibitor VVD-130850STAT-3 inhibitor VVD-130850STAT 3 inhibitor VVD-130850
02
Targets
STAT3 (Signal Transducer and Activator of Transcription 3)
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