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VX-708 + itraconazole
- Development stage
- Unknown
- Lead developer
- Vertex
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
VX-708 + itraconazole is a combination of two drugs: VX-708, a small molecule inhibitor developed by Vertex Pharmaceuticals that blocks voltage-gated sodium channels (VGSCs), and itraconazole, an antifungal agent commonly known for potentiating drug-drug interactions via CYP3A4 inhibition. VX-708 is under investigation for nervous system diseases, particularly pain, with phase 1 clinical trials evaluating its safety and pharmacokinetics in healthy participants. The combination with itraconazole is likely employed to study potential pharmacokinetic interactions, as itraconazole is a strong CYP3A4 inhibitor and may alter the metabolism of VX-708, but there are no approvals or specific disease indications reported for this exact combination.
- Other names
- VX 708VX708VX-708
02
Targets
CYP3A4 (Cytochrome P450 3A4)CYP51A1 (Sterol 14α-demethylase)
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