Drug intelligence / Profile preview

VX-A904

Development stage
Preclinical
Lead developer
VERAXA Biotech
Modality
Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics, T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

VX-A904 is an experimental therapeutic candidate developed by VERAXA Biotech, utilizing their proprietary BiTAC-ADC (bispecific T-cell engager antibody-drug conjugate) platform. This novel modality is designed to provide a synergistic anti-tumor effect by combining the targeted delivery of a cytotoxic payload, characteristic of antibody-drug conjugates, with the recruitment and activation of T cells at the tumor site, characteristic of bispecific T-cell engagers. Currently in the discovery stage, VX-A904 is being investigated for the treatment of various solid tumors, specifically lung cancer, ovarian cancer, and breast cancer. The specific tumor-associated antigens targeted by this molecule have not yet been disclosed.

02

Targets

CD3 (T-cell surface glycoprotein CD3)

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