Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
VXA-H5-02
- Development stage
- Preclinical
- Lead developer
- Vaxart
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Oral
01
Overview
VXA-H5-02 is a second-generation oral mucosal vaccine candidate being developed by Vaxart for the prevention of H5N1 avian influenza (highly pathogenic avian flu). Built on Vaxart's recombinant adenovirus serotype 5 (rAd5) oral vaccine platform, it encodes the hemagglutinin (HA) antigen from H5N1 clade 2.3.4.4b as its active immunogen. The vaccine is formulated as an enteric-coated tablet designed to induce both mucosal (IgA/IgG in nasal and gut mucosa) and systemic (serum neutralizing antibody) immune responses. In preclinical ferret studies, VXA-H5-02 demonstrated 100% survival against a lethal H5N1 clade 2.3.4.4b challenge, a significant reduction in viral shedding, and cross-neutralizing activity against divergent H5 strains, including clade 2.3.2.1e. It features enhanced antigen expression and a tet operator sequence to suppress transgene expression during manufacturing compared to the first-generation candidate ND1.1.
02
Targets
H5 HA (Influenza A hemagglutinin H5)HA (Hemagglutinin)
Beyond the preview
Go deeper on VXA-H5-02.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on VXA-H5-02.