Waferyl

Waferyl is a sublingual fentanyl wafer formulation developed by iX BioPharma using its proprietary WaferiX platform. It contains fentanyl, a small-molecule $\mu$-opioid receptor agonist, and is designed for the rapid treatment of pain. The formulation is a freeze-dried (lyophilized) wafer that dissolves rapidly under the tongue, facilitating fast systemic absorption and bypassing first-pass metabolism. Clinical studies in Australia have evaluated its pharmacokinetics and bioavailability, demonstrating rapid detection in plasma and significant absolute bioavailability in healthy volunteers.

Brand names

Waferyl

Other names

fentanyl sublingual wafer