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Wai Gan Qing Re Jie Du Decoction
- Development stage
- Unknown
- Lead developer
- Shanghai Municipal Hospital of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Wai Gan Qing Re Jie Du Decoction is a Traditional Chinese Medicine (TCM) herbal formulation developed by the Shanghai Municipal Hospital of Traditional Chinese Medicine. It is primarily investigated as an adjunctive therapy for sepsis-induced acute lung injury (ALI). The decoction is designed to clear heat and detoxify (Qing Re Jie Du), targeting the systemic inflammatory response and blood-gas barrier injury associated with sepsis. Clinical evaluation focuses on its ability to improve respiratory function and modulate biomarkers of lung injury, such as the Receptor for Advanced Glycation End-products (RAGE), Krebs von den Lungen-6 (KL-6), and Surfactant Protein D (SP-D).
- Other names
- Wai Gan Qing Re Jie Du Tang
02
Targets
MUC1 (Mucin-1 Antigen)SFTPD (Pulmonary surfactant protein D)AGER (RAGE)
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