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walnut oil
- Development stage
- Unknown
- Lead developer
- Shiraz University of Medical Sciences
- Administration
- Oral
01
Overview
Walnut oil is a natural botanical oil extracted from the seeds of the English walnut (*Juglans regia*). It is highly enriched in polyunsaturated fatty acids (PUFAs), particularly linoleic acid and alpha-linolenic acid (ALA), an omega-3 fatty acid. Walnut oil is primarily utilized as a dietary supplement and nutraceutical for its antioxidant, anti-inflammatory, and lipid-lowering properties. Clinical studies have demonstrated its efficacy in improving lipid profiles in patients with hyperlipidemia and type 2 diabetes, significantly reducing total cholesterol, low-density lipoprotein (LDL), and triglycerides. In preclinical research, walnut oil has also shown potential cardioprotective effects, such as mitigating letrozole-induced cardiotoxicity in zebrafish models by preventing the downregulation of G-protein coupled estrogen receptor 1 (GPER1) and modulating nitric oxide synthase 1 (NOS1) expression.
- Other names
- Juglans regia seed oilPersian walnut oil
02
Targets
ASIC (ASIC family)FXR (Farnesoid x-activated receptor)GPER1 (G protein-coupled estrogen receptor 1)NR1H3 (Liver X receptor beta)NOS1 (nNOS)PXR (Pregnane X receptor)SCD1 (Stearoyl-CoA desaturase 1)
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