Warburgia salutaris leaf extract

Warburgia salutaris leaf extract is a research-stage botanical extract derived from the leaves of the pepper-bark tree (*Warburgia salutaris*), a plant native to Southern Africa with a history of traditional medicinal use. Academic research has primarily investigated the extract's potential anticancer properties, particularly against MCF-7 breast cancer cells, where it demonstrates antiproliferative and pro-apoptotic effects. Mechanistically, the extract appears to induce DNA damage and trigger the intrinsic apoptotic pathway, characterized by the upregulation of pro-apoptotic Bax and Caspase-3, alongside the downregulation of anti-apoptotic Bcl-2. Additionally, the extract has been studied for its traditional applications, which include anti-inflammatory, antimicrobial, and antimalarial activities.

Other names

Warburgia salutaris leaf extracts