Drug intelligence / Profile preview

warfarin

Development stage
Approved
Lead developer
Wisconsin Alumni Research Foundation
Modality
Small Molecules
Administration
Oral
01

Overview

Warfarin is an oral anticoagulant (blood thinner) used to prevent and treat blood clots. It works by inhibiting the synthesis of vitamin K-dependent clotting factors in the liver, thereby reducing the blood's ability to clot. Warfarin is commonly prescribed for conditions such as atrial fibrillation, venous thromboembolism (including deep vein thrombosis and pulmonary embolism), and after heart valve replacement surgery[5][6][8]. Patients taking warfarin require regular monitoring of their International Normalized Ratio (INR) to ensure therapeutic efficacy and minimize bleeding risk[2][3]. Dietary intake of vitamin K can affect warfarin’s effectiveness; therefore, patients are advised to maintain a consistent diet regarding foods rich in vitamin K[3][4].

Brand names
CoumadinJantovenMarevan
Other names
华法林香豆素
02

Targets

VKORC1 (Vitamin K epoxide reductase complex subunit 1)

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