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Warming kidney spleen formula granules is a Traditional Chinese Medicine (TCM) preparation developed by the China Academy of Traditional Chinese Medical Sciences. It is designed to address 'Kidney-Yang' and 'Spleen-Yang' deficiencies, which are TCM patterns often associated with chronic immune exhaustion and metabolic decline. The formula is primarily investigated as an adjunctive therapy for advanced HIV/AIDS patients, specifically those classified as immune non-responders who fail to achieve adequate CD4+ T-cell recovery despite long-term highly active antiretroviral therapy (HAART). The therapeutic rationale suggests that the formula improves immune function by modulating energy metabolic pathways and enhancing T-cell activity.
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