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Drug intelligence / Profile preview
wasabi sulfinyl
- Development stage
- Preclinical
- Lead developer
- Kinjirushi
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Wasabi Sulfinyl is a dietary supplement and functional food ingredient developed by Kinjirushi Co., Ltd., derived from the rhizomes and roots of Japanese wasabi (*Eutrema japonicum*). Its primary active component is 6-methylsulfinylhexyl isothiocyanate (6-MSITC), also known as hexaraphane. Wasabi Sulfinyl is marketed and studied for its potential to improve cognitive functions, such as memory, attention, and judgment, particularly in middle-aged and older adults. It is also investigated for its neuroprotective, antioxidant, and anti-inflammatory properties, with research interest extending to chronic fatigue syndrome (ME/CFS), brain fog, metabolic syndrome, and neurodegenerative diseases like Alzheimer's and Parkinson's disease. Mechanistically, it acts on multiple pathways, including Nrf2/Keap1-ARE activation, GSK-3β inhibition, and modulation of PPAR, AMPK, PI3K/Akt/mTOR, and MAPK signaling.
- Brand names
- Wasabi SulfinylWasabi-sulfinyl
- Other names
- 6-methylsulfinylhexyl isothiocyanate6-MSITChexaraphanehexalaphane
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)GSK3 (Glycogen synthase kinase 3 beta)KEAP1 (Kelch-like ECH-associated protein 1)PPARA (Peroxisome proliferator-activated receptor alpha)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)
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