washed leukoreduced irradiated blood cells

Washed leukoreduced irradiated blood cell transfusions represent a specialized biological product used primarily in high-risk clinical settings, such as pediatric cardiac surgery. The preparation involves three distinct processing steps: **washing**, which replaces donor plasma with saline to remove inflammatory mediators (e.g., IL-6, IL-10), extracellular potassium, and plasma proteins that cause allergic reactions; **leukoreduction**, which removes donor white blood cells to prevent febrile non-hemolytic transfusion reactions and HLA alloimmunization; and **irradiation**, which uses ionizing radiation to inactivate donor T-lymphocytes, thereby preventing Transfusion-Associated Graft-Versus-Host Disease (TA-GVHD). This combination is specifically investigated for its ability to mitigate the systemic inflammatory response syndrome (SIRS) associated with cardiopulmonary bypass in children undergoing repair of congenital heart defects.

Other names

washed leukoreduced irradiated blood cell transfusionswashed RBCsleukoreduced RBCsirradiated RBCswashed red blood cells