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washed microbiota transplantation
- Development stage
- Phase 2
- Lead developer
- The Second Hospital of Nanjing Medical University
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral, Rectal, Nasogastric, Nasoduodenal, Intracolonic
01
Overview
Washed Microbiota Transplantation (WMT) is an optimized form of fecal microbiota transplantation (FMT) that utilizes an automated purification system and multiple centrifugal washing steps to prepare a precise microbiota suspension. Developed primarily by researchers in China (notably at Nanjing Medical University and Guangdong Pharmaceutical University), WMT aims to improve the safety and efficacy of traditional FMT by removing pro-inflammatory metabolites, mucus, and debris from donor feces. This process reduces the incidence of adverse events and allows for more standardized dosing. WMT is being investigated for a wide range of conditions, including inflammatory bowel diseases (ulcerative colitis, Crohn's disease), metabolic disorders (metabolic syndrome, obesity), and dermatological conditions (atopic dermatitis), by restoring gut microbiota homeostasis and modulating host metabolism.
- Other names
- washed fecal microbiota transplantationwashed microbiota suspensionwashed fecal microbiota
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