Drug intelligence / Profile preview

watermelon frost

Development stage
Unknown
Lead developer
Guilin Sanjin Pharmaceutical
Administration
Topical
01

Overview

Watermelon Frost is a Traditional Chinese Medicine (TCM) formulation primarily used for treating oral and throat ailments such as pharyngitis, mouth ulcers, and sore throat. It is traditionally prepared by packing a watermelon with mirabilite (sodium sulfate) and allowing it to ferment/effloresce, resulting in a white frost on the surface. Modern formulations, such as the Watermelon Frost Oral Spray, often combine this frost with other herbal ingredients like borneol, phellodendron bark, and coptis rhizome to provide anti-inflammatory, analgesic, and cooling effects. In clinical settings, it is being investigated for its efficacy in relieving post-operative dry mouth and sore throat following procedures like thoracoscopic lobectomy.

Brand names
Sanjin Watermelon Frost
Other names
Xi Gua ShuangWatermelon Frost Oral Spray
02

Targets

TRPA1 (Transient receptor potential cation channel subfamily A member 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)TRPV3 (Transient receptor potential vanilloid subtype 3)

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