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WBF-038
- Development stage
- Unknown
- Lead developer
- Pendulum Therapeutics
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
WBF-038 is a synbiotic formulation consisting of five probiotic strains combined with prebiotics, designed to improve metabolic health and bone density. It is currently being evaluated in a Phase 2 clinical trial led by the Mayo Clinic for its ability to prevent bone loss in patients with early-stage hormone receptor-positive breast cancer who are initiating adjuvant endocrine therapy with aromatase inhibitors. By modulating the gut microbiome, WBF-038 aims to mitigate the adverse effects of estrogen depletion, such as increased bone turnover, weight gain, and impaired glucose metabolism.
- Other names
- 5-strain probiotic formulation
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