wee1 inhibitor ii

Wee1 Inhibitor II is a potent, cell-permeable, and highly selective small molecule inhibitor of the Wee1 kinase, a critical regulator of the G2/M cell cycle checkpoint. By inhibiting Wee1, the compound prevents the inhibitory phosphorylation of Cdc2 (CDK1) at Tyr15, which promotes premature entry into mitosis and can lead to mitotic catastrophe in DNA-damaged cells. While primarily utilized as a research tool in oncology to study cell cycle arrest and DNA damage repair mechanisms, recent neurobiology research has identified its role in modulating the Nav1.2 channelosome. Specifically, Wee1 Inhibitor II has been shown to disrupt the interaction between fibroblast growth factor 14 (FGF14) and the voltage-gated sodium channel Nav1.2, thereby influencing neuronal excitability and firing properties. It is widely used in vitro and in cell-based assays to interrogate Wee1-mediated signaling pathways.

Other names

6-butyl-4-(2-chlorophenyl)-2-((4-(diethylamino)butyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-oneCalbiochem 681291Calbiochem681291Calbiochem-681291