Drug intelligence / Profile preview

weifuchun + hydrotalcite + l-glutamine + sodium gualenate

Development stage
Unknown
Lead developer
Huadong Medicine
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

This combination therapeutic regimen is widely used in China for the treatment of chronic atrophic gastritis (CAG) and the prevention of gastric cancer. It consists of **Weifuchun**, a traditional Chinese medicine (TCM) capsule developed by Huadong Medicine that contains *Isodon amethystoides*, *Pseudostellaria heterophylla*, and *Citrus aurantium* to improve mucosal blood flow and reverse intestinal metaplasia; **hydrotalcite**, an antacid and mucosal protectant that neutralizes gastric acid and binds bile acids; and a combination of **l-glutamine** and **sodium gualenate** (guaiazulene sodium sulfonate), which promotes mucosal repair by stimulating hexosamine synthesis and providing direct anti-inflammatory effects. The regimen is clinically valued for its ability to alleviate symptoms such as epigastric pain and bloating while promoting the histological recovery of the gastric mucosa.

Brand names
TalcidMarzulene
Other names
Weifuchun + Hydrotalcite + L-Glutamine and Guaiazulene Sodium Sulfonate Granules

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