Drug intelligence / Profile preview

WEIGHTAIN

Development stage
Preclinical
Lead developer
Ingredion
Modality
Microbiome Therapeutics
Administration
Oral
01

Overview

WEIGHTAIN is a proprietary nutraceutical satiety ingredient developed by Ingredion Incorporated for weight management. It is a co-processed composite formulation consisting of a viscous dietary fiber (specifically the hydrocolloid guar gum) and whole-grain high-amylose corn flour, which serves as a rich source of type 1 and type 2 resistant starch (HAM-RS). The ingredient works through multiple biological mechanisms: the viscous fiber component increases gastrointestinal viscosity to slow gastric emptying and prolong nutrient absorption, while the resistant starch undergoes fermentation by colonic microbiota to produce short-chain fatty acids (SCFAs). These SCFAs activate G-protein coupled receptors, including free fatty acid receptor 2 (FFAR2) and free fatty acid receptor 3 (FFAR3), triggering the release of anorexigenic hormones such as glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). These hormones signal satiety to the brain and suppress appetite. WEIGHTAIN is designed to be incorporated into various food products such as bars, muffins, smoothies, and baked goods to help manage obesity and overweight conditions.

Brand names
WEIGHTAIN
Other names
HAM-RS compositeguar gum and high-amylose corn flour composite
02

Targets

GLP1R (GLP-1R)FFAR3 (Free fatty acid receptor 3)Neuropeptide GPCR (Neuropeptide gpcrs (NT/SST/BB))FFAR2

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