Weishi Bitong Xifang

Weishi Bitong Xifang is a **traditional Chinese medicine (TCM) external herbal preparation** primarily used as a *fumigation and washing therapy* for knee osteoarthritis (KOA)[1][3][4][5]. The formula is composed of a blend of herbal ingredients (such as Semiliquidambar cathayensis, Radix zanthoxyli, Radix aconiti kusnezoffii, Radix aconite, Tinospora sinensis, Erythrina indica, Rheum officinale, and Cassia twig)[2]. Its proposed mechanisms derive from TCM theory—promoting blood circulation, removing stasis, and relieving pain and joint stiffness. Although precise molecular targets are unknown, clinical studies suggest improved pain and function scores and a favorable safety profile compared with standard topical NSAID therapy[1][3][5]. No detailed mechanism of action at the level of modern pharmacology has been demonstrated.