Drug intelligence / Profile preview

Weiyan Tongluo Granules

Development stage: Preclinical
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Weiyan Tongluo Granules (WYTLG) is a Traditional Chinese Medicine (TCM) formulation developed for the management of gastric intestinal metaplasia (GIM), a precancerous condition characterized by the replacement of gastric mucosa with intestinal-like epithelium. The formulation consists of a complex mixture of 29 identified active components that collectively exert therapeutic effects by modulating the PPARγ/NF-κB/CDX2 signaling axis. Specifically, WYTLG acts as a modulator of this pathway, leading to the attenuation of inflammatory responses, enhancement of resistance to apoptosis in gastric glands, and restoration of gastric mucosal function. Preclinical studies have demonstrated its potential in preventing gastric malignant transformation by regulating GIM-related biomarkers and improving gastric injury.

Brand names: Weiyan Tongluo Granules
Other names: 胃炎通络颗粒Weiyan Tongluo

Targets

PPARG (Peroxisome proliferator-activated receptor gamma)NF-κBCDX2 (Caudal type homeobox 2)

Beyond the preview

Go deeper on Weiyan Tongluo Granules.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Weiyan Tongluo Granules.

Explore the full profile