Drug intelligence / Profile preview

weizmannia coagulans SANK70258

Development stage
Preclinical
Lead developer
Mitsubishi Chemical
Modality
Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
Administration
Oral
01

Overview

Weizmannia coagulans SANK70258 is a spore-forming, lactic acid-producing probiotic bacterium being investigated for various health benefits. As a live biotherapeutic, it modulates the gut microbiome and has direct immunomodulatory effects. Its spore-forming nature makes it resistant to heat and acid, allowing it to reach the intestine alive. Research has explored its potential in ulcerative colitis (UC) by enhancing the production of butyrate, an anti-inflammatory short-chain fatty acid, especially when combined with other specific bacteria. The bacterium is also being studied for its ability to relieve symptoms of upper respiratory tract infections, improve constipation, and enhance skin health. Many of the studies are authored by researchers from Mitsubishi Chemical Corporation, who manufacture the strain.

Brand names
Lacris-SLACRIS
Other names
Bacillus coagulans SANK 70258Heyndrickxia coagulans SANK70258
02

Targets

NOD2 (Nucleotide-binding oligomerization domain-containing protein 2)TLR2 (Toll-like Receptor 2)

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