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Wen-Jing Hua-Yu Tong-Luo Decoction

Development stage: Preclinical
Lead developer: Longhua Hospital Shanghai University of Traditional Chinese Medicine
Administration: Oral

Overview

Wen-Jing Hua-Yu Tong-Luo Decoction is a traditional Chinese medicine (TCM) herbal formula developed by Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine. It is formulated as a small compound consisting of three main ingredients: Quanxie (scorpion), Chuanxiong (ligusticum wallichii), and Guizhi (cassia twig). The decoction is designed to warm the meridians, resolve stasis, and unblock collaterals. It is primarily being evaluated in clinical trials for the treatment and relief of chemotherapy-induced peripheral neuropathy (CIPN), particularly in patients undergoing chemotherapy regimens such as those containing oxaliplatin.

Other names: Wen-Jing Hua-Yu Tong-Luo FormulaWenjing Huayu Tongluo DecoctionWenjing Huayu Tongluo FormulaWenjing Huayu Tongluo Small Compound温经化瘀通络方温经化瘀通络汤

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)ESR1 (ERα)EGFR T790M (Epidermal growth factor receptor T790M mutant)IL-6 (Interleukin 6)

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