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Wen-Shen Juan-Bi-Tang

Development stage: Unknown
Modality: Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration: Oral

Overview

Wen-Shen Juan-Bi-Tang is a traditional Chinese herbal formula used primarily for musculoskeletal disorders characterized by wind-cold-damp bi syndrome with underlying deficiency of kidney yang or qi and blood. The name translates as "Warm the Kidney and Remove Painful Obstruction Decoction." It is a modification of the classical formula "Juan Bi Tang," which itself is widely used to treat joint pain, muscle aches, rheumatism, arthritis, and chronic pain conditions associated with cold-dampness obstructing the channels. The addition of warming herbs in Wen-Shen (meaning "warm kidney") versions targets patients with signs of internal cold or yang deficiency. Mechanistically in TCM theory, it dispels wind-dampness from the meridians/joints while tonifying kidney yang/qi to restore circulation and relieve pain. Its mechanism according to modern pharmacology may involve anti-inflammatory effects and modulation of immune response[4][5].

Brand names: Wen-Shen Juan-Bi-Tang
Other names: 溫腎蠲痺湯Wen Shen Juan Bi Tangmodified Juan Bi Tangwarm the kidney and remove painful obstruction decoction

Targets

STAT3 (Signal Transducer and Activator of Transcription 3)IL-6 (Interleukin 6)MMP9 (Matrix metalloproteinase-9)TP53 (Cellular Tumor Antigen p53 R175H)

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