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Wendan
- Development stage
- Phase 2
- Lead developer
- Xiyuan Hospital
- Administration
- Oral
01
Overview
Wendan is a Traditional Chinese Medicine (TCM) formulation, often administered as a tablet or decoction, primarily used to treat disorders associated with phlegm-heat internal disturbance syndrome. Developed and studied by institutions like Xiyuan Hospital of the China Academy of Chinese Medical Sciences, it is being evaluated for the treatment of mild to moderate generalized anxiety disorder (GAD). The formula typically contains ingredients such as *Bambusae Caulis in Taeniam* (Zhu Ru), *Aurantii Fructus Immaturus* (Zhi Shi), and *Pinelliae Rhizoma* (Ban Xia). Its mechanism of action involves regulating Qi, resolving phlegm, and clearing heat from the gallbladder and stomach to alleviate symptoms of restlessness, insomnia, and anxiety.
- Brand names
- Wendan tablet
- Other names
- Wendan TangWendan DecoctionWendan KeliWendan Pian
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CASP3 (Caspase-3)EGFR (Epidermal growth factor receptor)ESR1 (ERα)IL-6 (Interleukin 6)MAPK3 (Mitogen-activated protein kinase 1)VEGFA (Vascular endothelial growth factor A)NET (Norepinephrine Transporter)
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