Drug intelligence / Profile preview

wenjing decoction

Development stage
Unknown
Lead developer
Third Affiliated Hospital of Zhejiang Chinese Medical University
Modality
Small Molecules
Administration
Oral
01

Overview

Wenjing decoction is a classic Traditional Chinese Medicine (TCM) formula originally recorded in the *Jin Kui Yao Lue* (Synopsis of Prescriptions of the Golden Chamber). It is a complex multi-herb formulation composed of 12 ingredients: *Evodiae Fructus*, *Angelicae Sinensis Radix*, *Paeoniae Radix Alba*, *Chuanxiong Rhizoma*, *Ginseng Radix*, *Asini Corii Colla*, *Glycyrrhizae Radix*, *Cinnamomi Ramulus*, *Ophiopogonis Radix*, *Moutan Cortex*, *Zingiberis Rhizoma Recens*, and *Pinelliae Rhizoma*. Primarily used for gynecological disorders characterized by "deficiency-cold" in the Chong and Ren meridians, it is frequently employed to treat endometriosis, dysmenorrhea, and irregular menstruation. The formula works by warming the meridians, dispelling cold, nourishing blood, and resolving blood stasis. Research conducted by The Third Affiliated Hospital of Zhejiang Chinese University has specifically investigated its efficacy in alleviating pelvic pain associated with endometriosis, suggesting a mechanism involving the regulation of the hypothalamic-pituitary-ovarian (HPO) axis and the inhibition of pro-inflammatory cytokines and prostaglandins within the pelvic microenvironment.

Other names
Wenjing-tangUnkei-toWJTWēn Jīng Tāng
02

Targets

AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)EGFR (Epidermal growth factor receptor)ESR1 (ERα)IL-6 (Interleukin 6)TP53 (Cellular Tumor Antigen p53 R175H)VEGFA (Vascular endothelial growth factor A)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PR (Progesterone receptor)TNFA (Tumor necrosis factor alpha (soluble))

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