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Wenjing Tongluo
- Development stage
- Unknown
- Lead developer
- Jiangsu Provincial Hospital of Traditional Chinese Medicine
- Modality
- Small Molecules
- Administration
- Oral, Topical
01
Overview
Wenjing Tongluo is a Traditional Chinese Medicine (TCM) formula developed by the Jiangsu Provincial Hospital of Traditional Chinese Medicine, specifically designed to address oxaliplatin-induced peripheral neuropathy (OIPN). The formula is based on the TCM principles of warming the meridians and unblocking the collaterals to treat symptoms such as numbness, tingling, and cold-induced pain associated with platinum-based chemotherapy. It typically comprises a combination of herbs including *Cinnamomi Ramulus*, *Paeoniae Radix Alba*, and *Astragali Radix*. Mechanistically, Wenjing Tongluo is thought to improve local blood circulation, reduce the expression of pro-inflammatory cytokines like TNF-α and IL-6, and protect peripheral nerve fibers from oxidative damage. It is commonly administered as an oral decoction or an external herbal soak (wash) for the hands and feet.
- Other names
- Wenjing Tongluo formulaWenjing Tongluo decoctionWenjing Tongluo granulesWenjing Tongluo prescriptionWenjing Tongluo wash
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)
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