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Wenshen Bugu Fang

Development stage: Preclinical
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Wenshen Bugu Fang is a Traditional Chinese Medicine (TCM) herbal decoction composed of 16 botanical ingredients, including Astragalus, Codonopsis, and Epimedium. It is primarily investigated for the management of aromatase inhibitor-associated musculoskeletal symptoms (AIMSS) in postmenopausal women with breast cancer. The formula is designed to "warm the kidney and strengthen the bone" (Wenshen Bugu) according to TCM principles, aiming to alleviate joint pain, stiffness, and bone loss associated with estrogen-depriving endocrine therapies. In clinical research, it is often evaluated as an oral solution administered twice daily, sometimes in combination with complementary therapies like acupoint thread embedding (ATE).

Other names: Wenshen Bugu Decoction温肾补骨方

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