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Wenshen Yangxue Granules

Development stage: Preclinical
Administration: Oral

Overview

Wenshen Yangxue Granules is a Traditional Chinese Medicine (TCM) formula primarily used for the treatment of infertility. According to TCM principles, it functions by "warming kidney-yang" and "nourishing blood." Modern scientific investigations suggest that this multi-ingredient herbal preparation improves endometrial receptivity and promotes follicular development. Its mechanisms are thought to involve the regulation of key signaling pathways such as PI3K, HIF-1α, and VEGF, which are crucial for endometrial angiogenesis. Additionally, it has been shown to influence the Sirt3/FOXO3a pathway, contributing to increased mitochondrial energy metabolism in oocytes. The formula is composed of numerous herbs, reflecting its complex traditional pharmacological approach.

Other names: 温肾养血颗粒Wenshen Yangxue decoctionWSYXD温肾养血方

Targets

SIRT3 (NAD-dependent protein deacetylase sirtuin-3)VEGFA (Vascular endothelial growth factor A)FOXO3 (Forkhead box protein O3)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)HIF1A (Hypoxia-inducible factor 1-alpha)

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