wenshenyang decoction

Wenshenyang decoction is a traditional Chinese herbal formula composed mainly of three herbs: Cistanche deserticola, Epimedium sagittatum, and Drynaria roosii[2][5]. It is designed to "tonify kidney yang" according to traditional Chinese medicine theory and is used primarily for chronic kidney disease, especially in patients with kidney yang deficiency[1][2][5]. Integrated metabolomics and network pharmacology analyses have shown that the core active components are quercetin, luteolin, and kaempferol, acting principally via modulation of linoleic acid metabolism, FcεRI signaling, unsaturated fatty acid biosynthesis, and multiple gene targets (PTGS2, AKT1, MMP9, EGFR, MMP2, ANGPTL4, FGFR1, SIRT3, glucocorticoid receptor)[2][5]. Preclinical and clinical studies indicate efficacy in improving renal function and alleviating CKD symptoms, with a mechanism involving multi-target regulation including anti-inflammatory, antioxidant, and cell-protective effects[1][2][5].

Other names

wenshenyang decoction