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wenxin keli
- Development stage
- Phase 4
- Lead developer
- Yiling Pharmaceutical
- Administration
- Oral
01
Overview
Wenxin Keli is a traditional Chinese medicine (TCM) preparation used for the treatment of cardiac arrhythmias, such as atrial and ventricular premature beats, and atrial fibrillation. [3, 8] It is manufactured by Shandong Buchang Pharmaceutical. [5] According to TCM theory, it 'benefits qi and nourishes yin, promotes blood circulation to remove stasis'. [5, 8] Its ingredients are Codonopsis root (Dangshen), Siberian Solomon's seal rhizome (Huangjing), Notoginseng root (Sanqi), Amber (Hupo), and Nardostachys root (Gansong). [2] Pharmacological studies suggest it has multi-ion channel blocking properties, including inhibiting late sodium currents, L-type calcium currents, and transient outward potassium currents, which contributes to its antiarrhythmic effects. [17]
- Brand names
- Wenxin Keli稳心颗粒
- Other names
- Wenxin GranuleWen Xin KeliHeart-stabilizing Granule
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)SCN5A (Sodium channel protein type 5 subunit alpha)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)PPARGC1A (Peroxisome proliferator–activated receptor gamma coactivator 1-alpha)CACNA1G (T-type Calcium Channel Protein Subunit Alpha-1G)
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