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Wenyang Tongluo Decoction
- Development stage
- Preclinical
- Administration
- Oral, Topical
01
Overview
Wenyang Tongluo Decoction is a traditional Chinese herbal formula used primarily in Traditional Chinese Medicine (TCM) for the treatment of conditions associated with "cold" and "stasis" syndromes, such as peripheral neuropathy and systemic sclerosis-related skin fibrosis. The decoction is typically composed of multiple herbs designed to warm yang (the body's vital energy), promote blood circulation, unblock meridians (channels), and alleviate pain or numbness. Mechanistically, studies suggest that similar formulas can exert anti-fibrotic effects by promoting apoptosis and inhibiting proliferation of fibroblasts through down-regulation of cell cycle proteins like cyclin D1 and survivin[1][2]. Clinical observations indicate its use as an external wash or fumigation therapy for chemotherapy-induced peripheral neurotoxicity[3]. The exact composition may vary by practitioner or region.
- Brand names
- Wenyang Tongluo Decoction
- Other names
- Wen Yang Tong Luo Tang温阳通络汤
02
Targets
BIRC5 (Survivin)CCND1 (Cyclin D1)
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