Drug intelligence / Profile preview

wheat flour extract

Development stage
Preclinical
Lead developer
ALK Abelló
Modality
Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Oral, Topical, Intradermal, Percutaneous
01

Overview

Wheat flour extract is an allergen extract used for specific immunotherapy to treat IgE-mediated allergies to wheat, such as occupational baker's asthma and rhinitis. [1, 2, 3, 4] Administered sublingually (SLIT) or via subcutaneous injection (SCIT), it works by gradually desensitizing the patient's immune system to wheat allergens. [1, 2, 3, 4] Clinical evidence from a small study on SLIT showed that treatment led to an improvement in symptoms, reduced use of traditional drug therapy, and a significant reduction in inflammatory markers like exhaled nitric oxide (FeNO) and eosinophil cationic protein (ECP). [1, 3, 4] The primary allergens in wheat responsible for baker's asthma are believed to be salt-soluble proteins, particularly from the α-amylase/trypsin inhibitor family. [10, 12]

Other names
wheatTriticum aestivumcommon wheatwhole wheatTritici aestivi levis semenTritici fructusTriticum vulgare (wheat)Xiao mai
02

Targets

IgE (Immunoglobulin E)

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