Drug intelligence / Profile preview

wheatgrass extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Wheatgrass extract is a natural product derived from the young plantlets of the common wheat plant, *Triticum aestivum*. It is recognized for its rich profile of phytoconstituents, including chlorophyll, vitamins, minerals, and phenolic compounds, which contribute to its antioxidant, detoxifying, and anti-inflammatory properties. Research indicates that wheatgrass extract may exert neuroprotective effects by modulating the ERK/Akt-CREB-BDNF signaling pathway. Specifically, it has been shown to upregulate neuroprotective markers such as Brain-Derived Neurotrophic Factor (BDNF) and cAMP Response Element-Binding protein (CREB), while simultaneously downregulating inflammatory markers like TNF-α. Furthermore, wheatgrass extract has demonstrated the ability to regulate tau protein phosphorylation and prevent its aggregation in the hippocampal region, suggesting potential therapeutic utility in treating age-related memory impairment and neurodegenerative conditions like Alzheimer's disease.

Other names
Triticum aestivum extract
02

Targets

AKT (RAC-alpha serine/threonine-protein kinase)CREB (Cyclic AMP response element-binding protein)BDNF (Brain-derived neurotrophic factor)MAPK3 (Mitogen-activated protein kinase 1)TNFA (Tumor necrosis factor alpha (soluble))MAPT (Microtubule-associated protein tau)

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