Drug intelligence / Profile preview

white mulberry leaf extract

Development stage
Unknown
Lead developer
Phynova
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

White mulberry leaf extract is a botanical extract derived from the leaves of the *Morus alba* tree. It is rich in bioactive compounds, most notably the iminosugar 1-deoxynojirimycin (DNJ), which acts as a potent competitive inhibitor of intestinal alpha-glucosidase enzymes. By temporarily blocking these enzymes, the extract slows the breakdown of complex carbohydrates and sucrose into simple sugars, thereby blunting postprandial blood glucose and insulin spikes. It is widely used as a dietary supplement and nutraceutical to support healthy glucose metabolism, improve insulin sensitivity, and manage prediabetes and type 2 diabetes.

Brand names
Reducose
Other names
Morus alba extractMorus alba leaf extractmulberry leaf extractwhite mulberry extract
02

Targets

AMY (Pancreatic alpha-amylase)Sucrase-Isomaltase

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