Drug intelligence / Profile preview

white mustard extract

Development stage
Phase 1
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Topical, Transdermal
01

Overview

White mustard extract is a botanical substance derived from the seeds of *Sinapis alba*. It contains bioactive compounds such as sinapine thiocyanate (ST) and various glucosinolates (e.g., sinalbin). In Traditional Chinese Medicine (TCM), it is frequently used as a percutaneous treatment (Bai Jie Zi) during the summer to prevent and treat winter respiratory diseases such as asthma and bronchitis. The extract exhibits immunomodulatory properties by enhancing the release of pro-inflammatory cytokines like interleukin 1β (IL-1β) and tumor necrosis factor α (TNF-α), and by modulating the density and morphology of epidermal Langerhans cells. Additionally, it possesses significant antibacterial activity against oral pathogens including *Streptococcus mutans* and *Lactobacillus* species, making it an effective ingredient in herbal toothpastes for reducing dental plaque and gingival inflammation. Beyond its direct therapeutic uses, it also serves as a natural emulsifier in pharmaceutical delivery systems.

Other names
Sinapis alba extractwhite mustard seed extractBai Jie ZiS. alba extract
02

Targets

NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)NOS2 (Nitric Oxide Synthase 2)KEAP1 (Kelch-like ECH-associated protein 1)

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