Drug intelligence / Profile preview

whitfield + zinc oxide

Development stage
Unknown
Modality
Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
Administration
Topical
01

Overview

Whitfield + zinc oxide is a topical combination therapy consisting of Whitfield's solution (or ointment) and zinc oxide. Whitfield's solution contains benzoic acid and salicylic acid, both of which have antifungal and keratolytic properties. Benzoic acid acts as an antimicrobial agent that helps prevent bacterial infection, while salicylic acid promotes the shedding of rough or dead skin cells. Zinc oxide is a mineral with skin-protective, soothing, anti-inflammatory, and mild antimicrobial effects; it forms a physical barrier on the skin to protect against irritants and moisture. This combination is primarily used for treating fungal foot infections (including those caused by dermatophyte and non-dermatophyte species), as well as other minor skin irritations or conditions where both antifungal action and barrier protection are desired[1][6]. The mechanism involves direct inhibition of fungal growth (benzoic/salicylic acids) combined with physical protection/soothing from zinc oxide.

Other names
whitfield solution + zinc oxidewhitfield ointment + zinc oxidebenzoic acid and salicylic acid + zinc oxide
02

Targets

Microbial cell membrane and cell wall interface

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