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wild type feline HER2 DNA vaccine
- Development stage
- Unknown
- Lead developer
- Wayne State University
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
The wild type feline HER2 DNA vaccine is a research-stage DNA vaccine construct encoding the unmodified (wild-type) feline HER2 protein. Developed by researchers at Wayne State University, it has been evaluated in outbred domestic cats as a potential veterinary immunotherapy for feline mammary carcinoma and as a comparative model for human breast cancer vaccines. The vaccine is administered via intramuscular electrovaccination (electroporation) to stimulate an immune response against HER2-overexpressing tumor cells. However, preclinical studies have shown that the wild-type construct has a limited ability to overcome immune tolerance compared to heterologous or point-mutated feline HER2 DNA vaccine variants, and it may even hinder immune activation by other vaccines.
- Other names
- pfeHER2pfeHER-2pfeHER 2wild-type feline HER2 DNA vaccine
02
Targets
ERBB3 (Erb-b2 receptor tyrosine kinase 3)HER2 (Receptor tyrosine-protein kinase erbB-2)ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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