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WIN-1001X

Development stage: Phase 2
Lead developer: Medi Help Line
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

WIN-1001X is an investigational **botanical extract** comprising 20% ethanol extracts of *Polygala tenuifolia*, *Angelica tenuissima*, and *Dimocarpus longan*. It was derived from a modified Korean traditional herbal formula and is being developed for Parkinson's disease. Preclinical studies in MPTP mouse and 6-hydroxydopamine rat models associated WIN-1001X with enhanced autophagy, preservation of tyrosine hydroxylase activity in dopaminergic brain regions, neuroprotection, and improvement of parkinsonian motor deficits. Onjisaponin B has been identified as one bioactive constituent with autophagosome-inducing activity. A randomized placebo-controlled Phase II study evaluated oral tablet doses of 400 mg, 800 mg, and 1200 mg in early Parkinson's disease.

Other names: 20% ethanol extract of Polygala tenuifolia, Angelica tenuissima, and Dimocarpus longan

Targets

Neuraminidase

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