WIN 55212-2

WIN 55212–2 is a synthetic aminoalkylindole derivative that acts as a potent agonist at cannabinoid receptors. It produces effects similar to those of cannabinoids such as tetrahydrocannabinol (THC) but has an entirely different chemical structure. The compound is a full agonist at both the CB1 and CB2 cannabinoid receptors with high affinity and has been shown to be a potent analgesic in animal models of neuropathic pain. Mechanistically, it activates p42 and p44 MAP kinase via receptor-mediated signaling pathways. In addition to its analgesic properties, it exhibits neuroprotective effects and anti-inflammatory actions through prevention of microglial activation. It also acts as an agonist at PPARα and PPARγ nuclear receptors[1][2][3].

Other names

(R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate(R)-(+)-WIN 55,212–2 mesylate saltWIN 55,212–2 MESYLATECS–754