Drug intelligence / Profile preview

witch hazel

Development stage
Phase 4
Lead developer
Dickinson Brands
Modality
Small Molecules
Administration
Topical, Rectal
01

Overview

Witch hazel is a botanical extract derived from the bark and leaves of the *Hamamelis virginiana* plant, native to North America. It is widely recognized as a topical astringent and anti-inflammatory agent. The primary active constituents are tannins, particularly hamamelitannin and proanthocyanidins, which facilitate the constriction of skin tissues and blood vessels by precipitating proteins. This action helps to soothe minor skin irritations, reduce swelling, and promote the healing of broken skin. Witch hazel is an FDA-approved over-the-counter (OTC) active ingredient commonly indicated for the treatment of hemorrhoids, insect bites, and minor skin abrasions. It also possesses antioxidant properties due to its high polyphenol content, which helps protect skin cells against oxidative stress.

Brand names
T.N. Dickinson'sThayersDickinson'sHumphreys
Other names
Hamamelis virginianaHamamelis waterWinterbloomSnapping hazelSpotted alder

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