Drug intelligence / Profile preview

witch hazel + benzocaine

Development stage
Phase 4
Lead developer
University of Miami
Modality
Small Molecules
Administration
Topical
01

Overview

This multimodal perineal analgesia protocol (MPAP) is a combination therapy being evaluated by the University of Miami for the management of postoperative perineal pain following vaginal surgeries such as perineorrhaphy or posterior colporrhaphy. The protocol consists of three components: medicated witch hazel pads (e.g., MAJOR Medi-Pads), which act as an astringent to reduce inflammation and swelling; a 20% benzocaine spray (e.g., Dermoplast), a local anesthetic that provides temporary pain relief by blocking sodium channels; and perineal ice packs for cryotherapy. This combination aims to provide a non-opioid alternative for managing localized pain and discomfort in the immediate postoperative period.

Brand names
DermoplastMAJOR Medi-Pads
Other names
witch hazel + benzocaine + ice packs
02

Targets

NaV (Voltage-gated sodium channels)

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