WKYMVm

WKYMVm is a synthetic hexapeptide (Trp-Lys-Tyr-Met-Val-D-Met) that acts as a potent agonist of the formyl peptide receptor (FPR) family, with high affinity for formyl peptide receptor 2 (FPR2) and formyl peptide receptor 1 (FPR1), and lower affinity for formyl peptide receptor 3 (FPR3). Originally identified from a synthetic peptide library, WKYMVm is widely utilized as a research tool to study immune cell regulation, inflammation, and angiogenesis. By activating FPRs on neutrophils, monocytes, macrophages, dendritic cells, T cells, and natural killer (NK) cells, WKYMVm stimulates chemotaxis, reactive oxygen species (ROS) production, and degranulation. Preclinical studies have investigated its potential therapeutic applications in various conditions, including inflammatory diseases, ischemic injury, wound healing, and fungal infections such as *Candida glabrata*.

Other names

H-Trp-Lys-Tyr-Met-Val-D-Met-NH2H-Trp-Lys-Tyr-Met-Val-D-Met-NH-2H-Trp-Lys-Tyr-Met-Val-D-Met-NH 2Trp-Lys-Tyr-Met-Val-D-MetTrp-Lys-Tyr-Met-Val-D-Met-NH2Trp-Lys-Tyr-Met-Val-D-Met-NH-2Trp-Lys-Tyr-Met-Val-D-Met-NH 2W peptideW-peptideWKYMVMWKYMVM-NH2WKYMVM-NH-2WKYMVM-NH 2