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Wnt-5a
- Development stage
- Preclinical
- Lead developer
- WntResearch
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Injection
01
Overview
Wnt-5a is a protein belonging to the Wnt family, which plays a critical role in various pathobiological processes, including tumor formation and dissemination. It primarily functions as a ligand for frizzled receptors (Fzds) and Receptor Tyrosine Kinase-like Orphan Receptor 2 (ROR2), activating non-canonical Wnt signaling pathways. Wnt-5a has demonstrated diverse biological effects, such as impairing the migration of epithelial cancer cells, enhancing aquaporin 2 (AQP2) expression in renal collecting ducts to ameliorate sepsis-induced acute kidney injury, stimulating diabetic corneal epithelial wound healing, and modulating metaplasticity at hippocampal synapses. It is also implicated in the progression of osteoarthritis and angiogenesis in psoriasis.
- Other names
- rhWnt5arhWnt-5arhWnt 5aWnt-5aWnt5aWnt 5arecombinant human Wnt-5a protein
02
Targets
FZD2 (Frizzled Receptor 2)ROR2
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