wogonoside

Wogonoside is a naturally occurring flavonoid glycoside, specifically the 7-O-glucuronide of wogonin, primarily found in traditional Chinese medicinal plants such as Scutellaria baicalensis. It exhibits potent **antitumor**, **anti-inflammatory**, **anticoagulant**, **anti-angiogenic**, and **antioxidant** activities. Mechanistically, wogonoside induces apoptosis via mitochondrial pathways (upregulation of Bax, downregulation of Bcl-2, activation of caspase-3/9), triggers endoplasmic reticulum (ER) stress-mediated cell death via activation of the IRE1α-TRAF2-ASK1 complex and the JNK pathway, and suppresses PI3K/Akt/mTOR/p70S6K signaling. It strongly inhibits angiogenesis by blocking vascular endothelial growth factor (VEGF) expression and Hedgehog signaling through Smoothened degradation, and may reduce inflammation by dual inhibition of NF-κB and the NLRP3 inflammasome. Wogonoside is being investigated as a lead compound for cancer therapy, especially in gastric, colon, and triple-negative breast cancers.

Other names

Wogonin 7-glucuronideWogonin7-glucuronideWogonin-7-glucuronideWogonin 7-β-D-glucuronideWogonin 7-O-β-D-glucuronideGlychionide BOroxindin5,7-Dihydroxy 8-methoxyflavone 7-glucuronide