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WP103
- Development stage
- Unknown
- Lead developer
- Wanbangde Pharmaceutical Group
- Modality
- Small Molecules
- Administration
- Injection
01
Overview
WP103 is a small molecule acetylcholinesterase inhibitor (AChEI) being developed by Wanbangde for the treatment of Neonatal Hypoxic-Ischemic Encephalopathy (HIE). It is a novel injection formulation of huperzine A, a sesquiterpene alkaloid that naturally occurs in the firmoss *Huperzia serrata*. By inhibiting the enzyme acetylcholinesterase, WP103 increases the concentration of acetylcholine in the central nervous system, which is intended to provide neuroprotective effects and mitigate brain injury caused by oxygen deprivation in newborns. The drug has been granted Rare Pediatric Disease Designation (RPDD) and Orphan Drug Designation (ODD) by the US FDA. Its Investigational New Drug (IND) application has been accepted by the FDA, moving the candidate into clinical development.
- Other names
- New Huperzine A Injection新石杉碱甲注射液
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